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Overview
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Reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas, and gastrointestinal mucosa. This antibody identifies normal neuroendocrinecells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, whichprobably correlates with the distribution of the antigen within neurosecretory vesicles. The expressionof synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Anti-synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.
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