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Overview
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PU.1 is a transcription factor that has been shown to be important for normal B-cell development.PU.1 belongs to the ETS family of transcription factors. It is expressed in the myeloid lineage and inimmature as well as mature B-lymphocytes, with the exception of plasma cells. PU.1 is essential duringearly B-cell differentiation. The absence of PU.1 results in total block of B-cell development at the pre-pro stage. Very little is known about PU.1 function in later stages of B-cell development. PU.1 does notseem to play a role in the end-stage of B-cell development and is not expressed in plasma cells. PU.1exerts an important role in the regulation of the expression of crucial B-cell proteins, such asimmunoglobulin (Ig) genes, and CD20 and its putative binding sites were also identified in thepromoters of CD79, CD10, and CD22. PU.1 binds to the 3' enhancer region of both the Ig kappa andlambda light chain genes and it also regulates the immunoglobulin heavy chain genes through theintron enhancer region.
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