Name: Anti-Human CD274/PD-L1 Monoclonal Antibody ( FITC Conjugated )
Price: 216.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.
- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG2b kappa
    
    Reactivity
    
    human
    
    Conjugate
    
    FITC
    
    Formulation
    
    PBS with 0.05% Proclin300, 1% BSA
    
    Storage
    
    Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
    
    Antigen
    
    B7-H1; PD-L1; Programmed cell death ligand 1; B7 homolog 1; B7-H; B7H1; PDL1; PDCD1L1; PDCD1LG1 (Gene ID:29126; UniProt:Q9NZQ7)
    
    * For research use only.
- Applications
  - Application
    
    Flow Cytometry