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Overview
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HSP60 is a protein encoded by the HSPD1 gene which is approximately 61 kDa. HSP60 is localised to the mitochondrion matrix and is involved in gene expression, transcriptional regulation, legionellosis and deadenylation-dependent mRNA decay. This protein falls under the chaperonin family. It is essential for the folding and assembly of newly imported proteins in the mitochondria. It also prevents misfolding and promote the refolding of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSP60 is expressed in liver, nervous system, blood, lung and skin. Mutations in the HSPD1 gene result in spastic paraplegia and leukodystrophy. STJ93621 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of HSP60 protein.
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