Name: Anti-HSP27 antibody
Price: 224.00 USD

Overview
- HSP27 is a protein encoded by the HSPB1 gene which is approximately 22, 7 kDa. HSP27 is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, RET signalling, the MAPK signalling pathway, apoptosis and the survival caspase cascade. It is a small heat shock protein which functions as a molecular chaperone maintaining denatured proteins in a folding-competent state. Through its molecular chaperone activity, it may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. It also plays a role in stress resistance and actin organization. HSP27 is expressed in all tissues with the highest levels found in the heart and striated and smooth muscle. Mutations in the HSPB1 gene may result in Charcot-Marie-Tooth disease. STJ93617 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of HSP27 protein.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Synthesized peptide derived from human HSP27 around the non-phosphorylation site of S15.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Heat Shock Protein Beta-1; Hspb1; 28 Kda Heat Shock Protein; Estrogen-Regulated 24 Kda Protein; Heat Shock 27 Kda Protein; Hsp 27; Stress-Responsive Protein 27; Srp27 (Gene ID:3315; UniProt:P04792)
  
  * For research use only