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Overview
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HMG-1 is a protein encoded by the HMGB1 gene which is approximately 24, 8 kDa. HMG-1 is localised to the nucleus, cytoplasm and cell membrane. It is involved in activated TLR4 signalling, cytosolic sensors of pathogen-associated DNA, the innate immune system and apoptosis induced DNA fragmentation. It is a multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus, it is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodelling, DNA repair and genome stability. HMG-1 is ubiquitously expressed in human tissues. Mutations in the HMGB1 gene may result in endophthalmitis. STJ96867 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal Antibody detects endogenous levels of HMG-1 protein.
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