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Overview
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HDAC1 is a protein encoded by the HDAC1 gene which is approximately 55, 1 kDa. HDAC1is localised to the nucleus. It is involved in notch signalling pathways and p53 signalling. This protein falls under the histone deacetylase family and is a component of the histone deacetylase complex. Histone acetylation and deacetylation plays a key role in the regulation of eukaryotic gene expression. It also interacts with a retinoblastoma tumour-suppressor protein which forms a complex that is key in controlling cell proliferation and differentiation. HDAC1 is ubiquitously expressed with higher levels in heart, pancreas and testis. Mutations in the HDAC1 gene may result in Rett syndrome. STJ97722 was developed from clone 4E1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of HDAC1.
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Overview
Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using HADC1 Mouse mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using HADC1 Mouse mAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Rat-spinal-cord tissue. 1, HDAC1 Mouse monoclonal antibody (4E1) was diluted at 1:200 (4°C, overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval (>98°C, 20min). 3, Secondary antibody was diluted at 1:200 (room tempeRature, 30min). Negative control was used by secondary antibody only.
Anti-HDAC1 antibody
Anti-HDAC1 antibody
Catalog Number:
A001053090STJ
Mfr. No.:
STJ97722
Price:
$224
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