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Overview
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Frizzled-7 is a protein encoded by the FZD7 gene which is approximately 63, 6 kDa. Frizzled-7 is localised to the cell membrane. It is involved in the Wnt signalling pathway and pluripotency, CDK-mediated phosphorylation and removal of Cdc6 and mTOR signalling pathway. It is a 7-transmembrane domain protein that is a receptor for Wnt signalling proteins. It may also be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and in differentiated tissues. Frizzled-7 is expressed highly in adult skeletal muscle and foetal kidney. Mutations in the FZD7 gene may result in exudative vitreoretinopathy and hepatocellular carcinoma. STJ93151 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Frizzled-7 protein.
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