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Overview
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FoxO1 is a protein encoded by the FOXO1 gene which is approximately 69, 6 kDa. FoxO1 is localised to the cytoplasm and nucleus. It is involved in RET signalling, common cytokine receptor gamma-chain family signalling pathways and immune response IL-23 signalling pathway. This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. It is a transcription factor that is the main target of insulin signalling and regulates metabolic homeostasis in response to oxidative stress. It is also a main regulator of redox balance and osteoblast numbers and controls bone mass. FoxO1 is ubiquitously expressed in human tissues. Mutations in the FOXO1 gene may result in rhabdomyosarcoma. STJ93123 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of FoxO1 protein.
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