Name: Anti-FLT3 antibody
Price: 297.00 USD

Overview
- This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  mouse; rat
  
  Immunogen
  
  A synthetic peptide corresponding to a sequence within amino acids 650-750 of human FLT3 (NP_004110. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Receptor-Type Tyrosine-Protein Kinase Flt3; Fl Cytokine Receptor; Fetal Liver Kinase-2; Flk-2; Fms-Like Tyrosine Kinase 3; Flt-3; Stem Cell Tyrosine Kinase 1; Stk-1; Cd Antigen Cd135 (Gene ID:2322; UniProt:P36888)
  
  * For research use only