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Overview
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FAK is a protein encoded by the PTK2 gene which is approximately 119, 2 kDa. FAK is localised to the cell membrane and cytoplasm. It is involved in ERK signalling, integrin pathway and EPH-ephrin signalling. It is a non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. FAK is ubiquitously expressed with Isoform 1 and isoform 6 expressed in lung fibroblasts. Mutations in the PTK2 gene may result in malignant glioma. STJ93024 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of FAK protein.
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