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Overview
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eIF4A1 is a protein encoded by the EIF4A1 gene which is approximately 46, 1 kDa. eIF4A1 is localised to the cytoplasm and cell membrane. It is involved in viral mRNA translation, deadenylation-dependent mRNA decay, regulation of lipid metabolism and insulin signalling-generic cascades. It is an ATP-dependent RNA helicase that is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. eIF4A1 is expressed in the liver, lung, nervous system, pancreas and skin. STJ97038 was developed from clone M8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous eIF4A1 protein.
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