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Overview
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eIF2 alpha is a protein encoded by the EIF2S1 gene which is approximately 36, 1 kDa. eIF2 alpha is localised to cytoplasmic granules. It is involved in viral mRNA translation, influenza A, translation factors, regulation of lipid metabolism and insulin signalling-generic cascades. It is an enzyme that catalyses the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction. eIF2 alpha is expressed in the liver, nervous system, lung, blood and kidney. Mutations in the EIF2S1 gene may result in Wolcott-Rallison syndrome and fatty liver disease. STJ92872 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of eIF2 alpha protein.
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