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Overview
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Dnmt3b is a protein encoded by the DNMT3B gene which is approximately 95, 7 kDa. Dnmt3b is localised to the nucleus. It is involved in the mesodermal commitment pathway and sulfur amino acid metabolism. It is a methyltransferase which is thought to function in genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. Dnmt3b is expressed ubiquitously with the highest expression in foetal liver, heart, kidney and placenta. Mutations in the DNMT3B gene may result in immunodeficiency-centromeric. STJ92753 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Dnmt3b protein.
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