Name: Anti-DDR2 antibody
Price: 297.00 USD

Overview
- Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 290-400 of human DDR2 (NP_001014796. 1).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Discoidin Domain-Containing Receptor 2; Discoidin Domain Receptor 2; Cd167 Antigen-Like Family Member B; Discoidin Domain-Containing Receptor Tyrosine Kinase 2; Neurotrophic Tyrosine Kinase-Receptor-Related 3; Receptor Protein-Tyrosine Kinase Tkt; Tyrosine-Protein Kinase Tyro10; Cd Antigen Cd167b (Gene ID:4921; UniProt:Q16832)
  
  * For research use only