Name: Anti-CTSC antibody
Price: 297.00 USD

Overview
- This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 25-134 of human CTSC (NP_001805. 3).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Dipeptidyl Peptidase 1; Cathepsin C; Cathepsin J; Dipeptidyl Peptidase I; Dpp-I; Dppi; Dipeptidyl Transferase Cleaved Into-Dipeptidyl Peptidase 1 Exclusion Domain Chain; Dipeptidyl Peptidase I Exclusion Domain Chain-Dipeptidyl Peptidase 1 Heavy Chain; Dipeptidyl Peptidase I Heavy Chain-Dipeptidyl Peptidase 1 Light Chain; Dipeptidyl Peptidase I Light Chain (Gene ID:1075; UniProt:P53634)
  
  * For research use only