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Overview
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COL2A1 is a protein encoded by the COL2A1 gene which is approximately 141, 7 kDa. COL2A1 is secreted into the extracellular space. It is involved in collagen chain trimerization, the integrin pathway, ERK signalling and focal adhesion. It is a fibrillar collagen that is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. COL2A1 isoform 2 is highly expressed in juvenile chondrocyte. Mutations in the COL2A1 gene may result in Spondyloepiphyseal dysplasia. STJ92387 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of COL2A1 protein.
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