Name: Anti-Cleaved-Caspase-8 p18 (S217) antibody
Price: 224.00 USD

Overview
- Caspase-8 is a protein encoded by the CASP8 gene which is approximately 55, 3 kDa. Caspase-8 is localised to the cytoplasm and is involved in the TNFR1 pathway, dimerization of procaspase-8 , activated TLR4 signalling, apoptosis signalling and toll-like receptor signalling pathways. This protein falls under the cysteine-aspartic acid protease family. It pays a role in the programmed cell death induced by Fas and various apoptotic stimuli. Caspase-8 isoform 1, 5 and 7 are expressed in a wide variety of tissues. Mutations in the CASP8 gene may result in a caspase-8 deficiency. STJ97641 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.This polyclonal antibody detects endogenous levels of fragment of activated caspase-8 p18 protein resulting from cleavage adjacent to S217.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Synthesized peptide derived from human Cleaved-Caspase-8 p18 (S217)
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Caspase-8; Casp-8; Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; Cap4; Fadd-Homologous Ice/Ced-3-Like Protease; Fadd-Like Ice; Flice; Ice-Like Apoptotic Protease 5; Mort1-Associated Ced-3 Homolog; Mach [Cleaved Into-Caspase-8 Subunit P18-Caspase-8 Subunit P10] (Gene ID:841; UniProt:Q14790)
  
  * For research use only