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Overview
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CD7 antigen is a 40-kDa cell surface glycoprotein that is a member of the immunoglobulin genesuperfamily. While its precise function is not known, it is suggested that CD7 plays a role in T-cellinteractions as it is one of the earliest T-cell lineage associated antigens expressed during T-cellontogeny. CD7 is expressed in thymocytes, mature peripheral T-cells, natural killer cells, and lymphoidand myeloid progenitors. CD7 is the most consistently expressed T cell antigen in lymphoblasticlymphomas and leukemias, and is therefore a useful marker in the identification of such neoplasticproliferations. In mature post-thymic T cell neoplasms, it is the most common pan-T antigen to beaberrantly absent and its absence in a T cell population is a useful pointer to a neoplastic conversion.
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- Properties
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Overview