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Overview
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CD284 is a protein encoded by the TLR4 gene which is approximately 95, 6 kDa. CD284 is localised to the cell membrane. It is involved in activated TLR4 signalling, toll-like receptor signalling pathways and the Th17 differentiation pathway. This protein falls under the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of the innate immunity. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. CD284 is expressed in the spleen, blood, lung, nervous system and kidney. Mutations in the TLR4 gene may result in the placenta, spleen and peripheral blood leukocytes. STJ92109 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of CD284 protein.
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