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Overview
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Human CD123, the 70 kd IL‐3 receptor α chain (IL‐3Rα), is associated with the 120‐140 kd β subunit. The β chain is shared with the receptors for interleukins IL‐5 and GM‐CSF. IL‐3Rα is expressed on hematopoietic progenitors and plays an important role in hematopoietic progenitor cell growth and differentiation. This antibody has been reported to block the binding of 125I‐IL‐3 to high and low affinity IL‐3 receptors. In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release, endothelial cell‐mediated IL‐8 secretion, and neutrophil transmigration. At the Fifth HLDA Workshop, the human IL‐3 receptor was designated CD123. This antibody reacts with plasmacytoid dendritic cells (PDC). PDC plays a crucial role in the initiation of antiviral and antitumoral immune responses and produce type I interferons a and b. CD123 antibody is useful in diagnosis of Kikuchi disease, hyaline vascular type of Castleman disease, lupus, and primary cutaneous marginal zone B‐cell lymphoma.
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