Name: Anti-Caspase-4 antibody
Price: 224.00 USD

Overview
- Caspase-4 is a protein encoded by the CASP4 gene which is approximately 43, 2 kDa. Caspase-4 is localised to the cytoplasm, cytosol and endoplasmic reticulum membrane. It is involved in the p53 signalling, the TRAF pathway, ceramide pathway and innate immune system. CASP4 is an essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation. It is involved in the signalling pathways of apoptosis, necrosis and inflammation. It is widely expressed, including keratinocytes and colonic and small intestinal epithelial cells. Mutations in the CASP4 gene may result in neuroblastoma. STJ92022 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-4 protein.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Synthesized peptide derived from human Caspase-4.
  
  Purification
  
  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Caspase-4; Casp-4; Ice And Ced-3 Homolog 2; Ich-2; Ice(Rel-II; Mih1; Protease Tx [Cleaved Into-Caspase-4 Subunit 1-Caspase-4 Subunit 2] (Gene ID:837; UniProt:P49662)
  
  * For research use only