Name: Anti-C10orf2 antibody
Price: 297.00 USD

Overview
- This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  mouse
  
  Immunogen
  
  A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of human C10orf2 (NP_068602. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Twinkle Protein-Mitochondrial; Progressive External Ophthalmoplegia 1 Protein; T7 Gp4-Like Protein With Intramitochondrial Nucleoid Localization; T7-Like Mitochondrial Dna Helicase; Twinkle Mtdna Helicase (Gene ID:56652; UniProt:Q96RR1)
  
  * For research use only