Name: Anti-BRCA1 antibody
Price: 340.00 USD

Overview
- The BRCA‐1gene codes for a nuclear phosphoprotein that plays a role in maintaininggenomic stability and acts as a tumor suppressor. The normal gene plays a role inrepairing breaks in DNA. If a mutation occurs in this gene the repair function maybecome disabled thus leading to more DNA replication errors and neoplastic growth.Current findings suggest that BRCA‐1 may play an as yet undefined protective role incells, as it is strongly expressed in epithelial cells undergoing high levels ofproliferation in association with differentiation. Additional findings have determinedthat complete loss of BRCA‐1 nuclear expression in breast cancer and the correlationwith poor prognostic markers imply that the altered BRCA‐1 phenotype may providean added prognostic parameter for breast cancer and could be applied for a potentialrapid screening technique to identify BRCA‐1 mutations
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1 kappa
  
  Reactivity
  
  human
  
  Clone
  
  MS110
  
  Immunogen
  
  BRCA‐1
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  * For research use only