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Overview
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Recognizes a protein of 95kDa, which is identified as Bcl‐6. Antibody to bcl‐6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B‐cell lymphoma. Follicular lymphoma will show bcl‐6 (and CD10) positivity whereas other small B‐cell lymphomas are usually negative.(2) Bcl‐6 is an important prognostic marker in diffuse large B‐cell lymphomas(DLBCL), where CD10, bcl‐6 and MUM1/IRF4 are used to identify germinal center and activated B‐cell phenotypes.(3) Bcl‐6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed‐Sternberg cells of classical Hodgkin lymphoma are bcl‐6 negative whereas the large (“L&H”) cells of NLPHL are bcl‐6 positive. In contrast, anti‐Bcl‐6 rarely stains mantle‐cell lymphoma and MALT lymphom
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