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Overview
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Bak is a protein encoded by the BAK1 gene which is approximately 23, 4 kDa. Bak is localised to the mitochondrion membrane. It is involved in apoptosis modulation and signalling, CDK-mediated phosphorylation and removal of Cdc6 and microRNAs in cancer. This protein falls under the BCL2 protein family. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. Bak is expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. Mutations in the BAK1 gene may result in benign mammary dysplasia and chronic gonococcal salpingitis. STJ91814 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Bak protein.
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