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Overview
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Recognizes human beta3 integrin subunit present in Platelet glycoprotein GPIIb-IIIa(integrin alphaIIb/ beta3, CD41/CD61) and in the vitronectin receptor (integrin alphaV/ beta3, CD51/CD61). Intergins are a family of heterodimeric membrane glycoproteins expressed on diversecell types which function as the major receptors for extracellular matrix and as cell-cell adhesionmolecules. As adhesion molecules they play an important role in numerous biological processes suchas platelet aggregation, inflammation, immune function, wound healing, tumour metastasis andtissue migration during embryogenesis. In addition integrins are involved in signaling pathways, transmitting signals both into an out from cells. All integrins consist of two non-covalently associatedsubunits, alpha and beta. At least 12 different alpha subunits and 8 beta subunits have beenidentified. The beta subunits all contain 56 conserved cysteines (except beta4 which has 48) which arearranged in four repeating units. The beta3 subunit is a 93kDa protein that contains a large loop in theN-terminus stabilized by intrachain disulphide bonding with the first cysteine-rich repeat.
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