Name: Anti-ALDH18A1 antibody
Price: 297.00 USD

Overview
- This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP-and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ALDH18A1 (NP_002851. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Delta-1-Pyrroline-5-Carboxylate Synthase; P5cs; Aldehyde Dehydrogenase Family 18 Member A1 Includes-Glutamate 5-Kinase; Gk; Gamma-Glutamyl Kinase-Gamma-Glutamyl Phosphate Reductase; Gpr; Glutamate-5-Semialdehyde Dehydrogenase; Glutamyl-Gamma-Semialdehyde Dehydrogenase (Gene ID:5832; UniProt:P54886)
  
  * For research use only