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Overview
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AFP alpha 1 Fetoprotein is a protein encoded by the AFP gene which is approximately 68, 6 kDa. AFP alpha 1 Fetoprotein is secreted into the extra cellular space. It is involved in hippo signalling pathway, embryonic stem cell differentiation pathways and FOXA2 and FOXA3 transcription factor networks. It is a major plasma protein produced by the yolk sac and the liver during fetal life. In adults, alpha-fetoprotein expression is often associated with hepatoma or teratoma and is thought to be the fetal counterpart of serum albumin. AFP alpha 1 Fetoprotein is expressed in the heart, liver, cells of the nervous system, lung and blood. Mutations in the AFP gene may result in an alpha-fetoprotein deficiency. STJ96977 was developed from clone 17C5 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous AFP proteins.
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