Name: Anti-Active Caspase-3 antibody
Price: 224.00 USD

Overview
- Active caspase-3 is a protein encoded by the CASP3 gene which is approximately 31, 6 kDa. Active caspase-3 is localised to the cytoplasm. It is involved in the TNFR1 pathway, apoptosis modulation and signalling and respiratory electron transport. This protein falls under the cysteine-aspartic acid protease family. It is a sequential activator of caspases and plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Active caspase-3 is highly expressed in lung, spleen, heart, liver and kidney. Mutations in the CASP3 gene may result in bladder urothelial carcinoma and primary effusion lymphoma. STJ97448 was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. This antibody detects endogenous active caspase-3 protein.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human; mouse; rat; chicken
  
  Clone
  
  5E1
  
  Immunogen
  
  Recombinant Protein
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS, pH 7.4, containing 0.5% BSA, 0.02% sodium azide and 50% Glycerol.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Caspase-3; Casp-3; Apopain; Cysteine Protease Cpp32; Cpp-32; Protein Yama; Srebp Cleavage Activity 1; Sca-1 [Cleaved Into-Caspase-3 Subunit P17-Caspase-3 Subunit P12] (Gene ID:836; UniProt:P42574)
  
  * For research use only