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Overview
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KEY FEATURES
• Recombinant chimeric (human Fc region)
• Suitable for dot blot, neutralization assay and serology ELISA
• Reacts with AAV5 intact capsids
• Isotype: IgG1
• Binding affinity: KD value (AAV5) = 8.1E-11 MPlease contact us at for specific academic pricing.
Background
Our human chimeric AAV antibodies are derived from our mouse monoclonal AAV antibodies and are a combination of the mouse antigen binding region and a human Fc region. Therefore, it provides the well-known characteristics of the corresponding mouse monoclonal antibody (anti-AAV5, ADK5b, Cat. No. 610149) like cross-reactivity and neutralization activity combined with a human Fc region allowing the use in an anti-human secondary antibody detection system.
Many humans in the general population have developed antibodies against AAV as a result of naturally acquired infections, which might affect efficacy and safety of the gene transfer using AAV vectors. Therefore, testing for pre-existing AAV antibodies in patient sera is an indispensable step for the selection of patients for AAV gene therapy clinical trials.
Our human chimeric AAV antibodies are close to the human derived samples, making them the ideal positive control for reproducible and comparable serological assays.More Details
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- Properties
- Applications
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