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Overview
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Calculated MW: 35kDa
Observed MW: 36kDaPlease contact us at for specific academic pricing.
Background
Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A. Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.
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