Anidulafungin

- Overview
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    Background
    
    Anidulafungin （LY-303366）is a synthetic derivative of echinocandin B, used as a drug of antifungal [1].
    Anidulafungin has been reported to inhibit systemic isolates of Candida species with the MIC90 values of 0.08μg/ml, 0.32μg/ml, 0.32μg/ml and 5.12μg/ml for C.albicans (n=99), C.glabrata(n=18), C.tropicalis(n=10), and C.parapsilosis (n=10), respectively. In addition, Anidulafungin has been found to be active against Aspergillus species(n=20) with the MIC90 values of ~0.02μg/ml. Apart from these, Anidulafungin has been revealed to inactively restrain with the MIC90 values of >10.24μg/ml and 16μg/ml, for C.neoformans and B.dermatitidis, respectively [1].
    
    [1] Zhanel GG1, Karlowsky JA, Harding GA, Balko TV, Zelenitsky SA, Friesen M, Kabani A, Turik M, Hoban DJ. In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species. Antimicrob Agents Chemother. 1997 Apr;41(4):863-5.
- Properties
  - Categories
    
    Antifungal drug
    
    CAS Number
    
    166663-25-8
    
    Molecular Formula
    
    C58H73N7O17
    
    Molecular Weight
    
    1140.24
    
    Appearance
    
    A solid
    
    Purity
    
    99.26%
    
    Solubility
    
    insoluble in EtOH; insoluble in H2O; ≥20.8 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O[[email protected]]1[[email protected]](C)CN(C([[email protected]]([[email protected]](C)O)NC([[email protected]]([[email protected]@H]([[email protected]@H](C(C=C2)=CC=C2O)O)O)NC([[email protected]](C3)N(C([[email protected]]([[email protected]](C)O)NC4=O)=O)C[[email protected]@H]3O)=O)=O)=O)[[email protected]@H]1C(N[[email protected]]([[email protected]@H](C[[email protected]@H]4NC(C5=CC=C(C6=CC=C(C(C=C7)=CC=C7OCCCCC)C=C6)C=C5)=O)O)O)=O
    
    * For Research Use Only
- Reference
  - 1. Hoyer AR, Johnson CJ, et al. "Echinocandin Treatment of Candida albicans Biofilms Enhances Neutrophil Extracellular Trap Formation." Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00797-18. PMID:29987146