Ang 1-7 (human, horse, sheep, pig, and rat)

- Overview
  - Ang 1-7 is a biologically active peptide of the renin-angiotensin system. Ang I-7 binds the Mas receptor, which mediates vasodilation and the antiproliferative actions of the heptapeptide. Endogenous Ang 1-7 is generated by angiotensin-converting enzyme 2 (ACE 2) mediated degradation of Ang II. It can also be formed from Ang I or Ang II by other peptidases.
    
    • Chemical Information
    Chemical name: angiotensin 1-7
    Sequence: Asp-Arg-Val-Tyr-Ile-His-Pro (or DRVYIHP)
    C-terminus: free acid; N-terminus: free amine
    Counter ion: trifluoroactate salt; Chemical formula: C41H62N12O11
    Molecular weight: 899.01; CAS number: 51833-78-4
    
    • Specification
    Physical appearance: lyophilized powder;
    Storage temp.: -20 °C
    Purity: ≥ 97 % by HPLC
    
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- Properties
  - Categories
    
    Peptides and Peptide Conjugates
    
    * For Research Use Only. Not for Use in Diagnostic Procedures.
- Reference
  - Recent reviews for Ang 1-7:
    
    Iusuf D, Henning RH, van Gilst WH, Roks AJ. Eur J Pharmacol. 2008 May 13;585(2-3):303-12. Epub 2008 Mar 15; 2. Santos RA, Ferreira AJ. Curr Opin Nephrol Hypertens. 2007 Mar;16(2):122-8; 3. Santos RA, Frézard F, Ferreira AJ. Curr Med Chem Cardiovasc Hematol Agents. 2005 Oct;3(4):383-91.
    
    Selected papers:
    
    Chappell, M.C., Brosnihan, K.B., Diz, D.I. and Ferrario, C.M. J. Biol. Chem., 1989, 264, 16518-16523; 2. Schiavone MT, Santos RA, Brosnihan KB, Khosla MC, Ferrario CM. Proc Natl Acad Sci USA 1988; 85: 4095–8; 3. Ferrario CM. Hypertension 2006; 47: 515–21; 4. Watanabe T, Barker TA, Berk BC. Hypertension 2005; 45: 163–9; 5. Santos RA, Castro CH, Gava E et al. Hypertension 2006; 47: 996–1002.

Ang 1-7 (human, horse, sheep, pig, and rat)

Ang 1-7 (human, horse, sheep, pig, and rat)

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