Andrographolide

Andrographolide

Catalog Number:
L002373308APE
Mfr. No.:
APE-N1855
Price:
$180
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          Background

          IC50: 11.0 ± 0.28 μg/ml for α-glucosidase; 11.3 ± 0.29 μg/ml for α-amylase Andrographolide is an irreversible antagonist of NF-κB. The nuclear factor NF-κB pathway has been considered as a prototypical proinflammatory signaling pathway, based on the role of NF-κB in the expression of proinflammatory genes including chemokines, cytokines and adhesion molecules.In vitro: Andrographolide was found to suppress the expression of inducible nitric oxide synthase in a concentration-dependent manner. In the andrographolide-treated group, a reduction of Akt, c-Jun N-terminal kinase and p65 phosphorylation was observed. Andrographolide also caused a decrease in Bcl-2/NF-κb expression and a dose-dependent increase in the expression of Cleaved-Caspase3/Bax protein [1]. In vivo: Rats were dosed with andrographolide intragastrically for 5 consecutive days in a hepatoprotection study. Results indicated that andrographolide could up-regulate glutamate cysteine ligase catalytic and modifier subunits, heme oxygenase-1, superoxide dismutase-1, glutathione S-transferase protein and mRNA expression in the heart, liver, and kidney [2]. Clinical trial: N/A

          [1] Wang ZM,Kang YH,Yang X,Wang JF,Zhang Q,Yang BX,Zhao KL,Xu LP,Yang LP,Ma JX,Huang GH,Cai J,Sun XC. Andrographolide radiosensitizes human esophageal cancer cell line ECA109 to radiation in vitro. Dis Esophagus.2016 Jan;29(1):54-61.
          [2] Chen HW,Huang CS,Li CC,Lin AH,Huang YJ,Wang TS,Yao HT,Lii CK. Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats. Toxicol Appl Pharmacol.2014 Oct 1;280(1):1-9.

      • Properties
        • Alternative Name
          (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
          CAS Number
          5508-58-7
          Molecular Formula
          C20H30O5
          Molecular Weight
          350.44
          Appearance
          A solid
          Purity
          99.67%
          Solubility
          insoluble in EtOH; insoluble in H2O; ≥16 mg/mL in DMSO
          Storage
          Store at -20°C

          * For Research Use Only

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