Amyloid Precursor Protein β-Secretase Inhibitor

Amyloid Precursor Protein β-Secretase Inhibitor
MW: 1651.8
H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-OH
This statin analogue of an amyloid precursor protein fragment is an effective inhibitor of β-secretase from human brain. β-secretase is responsible for proteolytic cleavage of N-terminal fragment from amyloid precursor protein between residues 671 and 672, leading to the generation of the soluble form of
amyloid precursor protein. The C-terminal fragment is further processed by gamma-secretase to form the amyloid β-peptide assumed to be the pathological component of Alzheimers's disease.
Sinha S. et al. (1999) Nature 402, 537.
1mg
5mg

Please contact us at for specific academic pricing.