Amlodipine Besylate

- Overview
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    Background
    
    Amlodipine besylate is a long-acting Ca2+ channel blocker that reduce blood pressure as an antihypertensive drugs.
    Calcium channel is an ion channel that selectively permeable to calcium ions. It serves vital functions in cellular signal transduction.
    In cortical neurons, treatment of amlodipine besylate (<= 5 um) rescued the viability of H(2) O(2) injured cell and elevated the free radicals levels. Amlodipine besylate exhibits neuroptorective effects, such as reducing oxidative stress, promoting survival signals and blocking death signals. [1] It also showed proliferative effect on human epidermoid carcinoma A431 cells.[2]
    In patient with exertional angina, amlodipine besylate reduced the total peripheral resistance and myocardial oxygen demand. In cat orally treated with amlodipine besylate daily, the average indirect systolic blood pressure were decreased without significant body weight/serum creatinine/potassium concentrations changes. [3]
    
    [1] Lee YJ, Park HH, Koh SH, Choi NY, Lee KY. Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress. J Neurochem. 2011 Dec;119(6):1262-70. doi: 10.1111/j.1471-4159.2011.07529.x.
    [2] Yoshida J, Ishibashi T, Nishio M. Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells. Eur J Pharmacol. 2003 Jul 4;472(1-2):23-31.
    [3] Henik RA, Snyder PS, Volk LM. Treatment of systemic hypertension in cats with amlodipine besylate. J Am Anim Hosp Assoc. 1997 May-Jun;33(3):226-34.
- Properties
  - Categories
    
    Block of L-type calcium channel
    
    Alternative Name
    
    benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
    
    CAS Number
    
    111470-99-6
    
    Molecular Formula
    
    C20H25ClN2O5·C6H6O3S
    
    Molecular Weight
    
    567.05
    
    Appearance
    
    A solid
    
    Purity
    
    99.99%
    
    Solubility
    
    ≥26.05 mg/mL in DMSO; insoluble in H2O; ≥11.26 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
    
    * For Research Use Only