Amino-dPEG®₁₂-t-butyl ester

Amino-dPEG®12-t-butyl ester product number 10281, is a single molecular weight, discrete length polyethylene glycol (dPEG®) crosslinker. The primary amine group on one end of the crosslinker reacts with carboxylic acids to form stable amide bonds. A tert-butyl ester group on the opposite end of the linker protects the amine-reactive carboxylic acid end of the molecule. Trifluoroacetic acid (TFA) effectively removes the protecting group, leaving the propionic acid moiety ready for further reaction.

PEGylation with dPEG® Products
Traditional PEGylation reagents are disperse polymers. These polymers consist of an intractable mixture of different lengths and molecular weights of polyethylene glycol chains. Although PEG provides tremendously beneficial modifications to biomolecules, the complexity caused by polymer dispersity creates enormous challenges to the analysis of the PEG-modified molecules.

In sharp contrast, our dPEG® products consist of a single, discrete chain length and molecular weight of PEG. The benefits of traditional PEGylation reagents remain. The analytical challenges of dispersed, polymeric PEG are gone.

Please contact us at for specific academic pricing.