AMI-1

AMI-1

Catalog Number:
L002368351APE
Mfr. No.:
APE-A1908
Price:
$212
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      • Overview
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          Background

          Potent, cell permeable and specific protein arginine N-methyltransferase 1 (PRMT1) inhibitor (IC50 = 8, 8 µM), Does not compete for the AdoMet (S-adenosyl-L-methionine, SAM) binding site, Blocks peptide substrate binding, HIV-1 RT polymerase inhibitor (IC50 = 5, 0 µM).

      • Properties
        • Alternative Name
          Arginine N - methyltransferase inhibitor - 1; sodium 7,7'-(carbonylbis(azanediyl))bis(4-hydroxynaphthalene-2-sulfonate)
          CAS Number
          20324-87-2
          Molecular Formula
          C21H14N2O9S2Na2
          Molecular Weight
          548.45
          Purity
          98.00%
          Solubility
          insoluble in EtOH; insoluble in DMSO; ≥19.1 mg/mL in H2O
          Storage
          Store at -20°C

          * For Research Use Only

      • Reference
        • 1. Bing Yao, Tao Gui, et al. "PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling." Genome Med. 2021 Apr 14;13(1):58. PMID:33853662

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