Name: ALX 5407 hydrochloride
Price: 502.00 USD

- Overview
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    Background
    
    ALX 5407 is a potent and selective inhibitor of the hGlyT1 glycine transporter. It completely inhibited glycine transport in the GlyT1 cells with an IC50 value of 3 nM [1].GlyT1 is a family of glycine transporters. Transporters terminate the actions of both glycine and glutamate. There are at least three splice variants in the GlyT1 family, called 1A, 1B, and 1C. GlyT1 is distributed widely throughout the CNS, and that distribution correlates better with the localization of N-methyl-D-aspartate (NMDA) receptors than with the strychnine-sensitive glycine receptor [1].QT6-1C cells were treated with 50 nM ALX 5407, and then were washed four times with HBS. After washing, 90 ?l of HBS was added. The rate at which ALX 5407 dissociated from the GlyT1C transporter was then measured. A long half-time was found. This indicates the binding of ALX 5407 to the GlyT1C transporter is essentially irreversible [1].Using microdialysis, it was found that in vivo in rat prefrontal cortex (PFC), administration of ALX 5407 at a dose of 10 mg/kg, p.o., resulted in an increase of 40% in PFC glycine levels measured 60 to 90 min after drug administration, whereas the lower dose at 1 mg/kg elicited a slight, nonsignificant elevation [1].
- Properties
  - Alternative Name
    
    (S)-2-((3-([1,1'-biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl)(methyl)amino)acetic acid hydrochloride
    
    CAS Number
    
    200006-08-2
    
    Molecular Formula
    
    C24H24FNO3·HCl
    
    Molecular Weight
    
    429.92
    
    Appearance
    
    White solid
    
    Purity
    
    98.00%
    
    Solubility
    
    <42.99mg/ml in DMSO; <21.5mg/ml in ethanol
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

ALX 5407 hydrochloride

ALX 5407 hydrochloride

Background

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