Alternariol

- Overview
  - Alternariol is a mycotoxin produced by Alternaria and is often found as a contaminant in fruit and small grain cereal products. Structurally, it is characterized as a dibenzopyranone. It can be used as an analytical standard. The product is soluble in methanol or DMSO.
    
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    Background
    
    Alternariol damages DNA and causes base oxidations and strand breaks, and phosphorylation (activation) of histone H2A and check point kinase-1 and 2 (Chk-1/2). Alternariol-induced DNA damage and resulting transcriptional changes in p21, MDM2 and Cyclin B contribute to a reduction of cell proliferation.
- Properties
  - CAS Number
    
    641-38-3
    
    Molecular Formula
    
    C14H10O5
    
    Molecular Weight
    
    258.2
    
    Appearance
    
    White to off-white solid
    
    Solubility
    
    Soluble in methanol or DMSO
    
    Other Properties
    
    Source: Alternaria sp.
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Alternariol is active against fungi.
    
    Eukaryotic Cell Culture Applications: Human colon carcinoma cells were used to elucidate the cell death mode and pathways triggered by Alternariol. The mycotoxin induced apoptosis and thus cell viability. It was mediated via a motochondria-dependent pathway. It does not target this organelle directly; its cytotoxicity is mediated by the activation of the mitochondrial pathway of apoptosis (Bensassi F et al, 2012).

Alternariol

Background

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