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Akt Inhibitor IV

Akt Inhibitor IV

Catalog Number:

FC01366537APE

Mfr. No.:

APE-C5867

Price:

$341

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- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner.1 Akt inhibitor IV inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC50 = 520 nM).2 It also reduces the growth of cancer cells (IC50 = 0.3 μM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ROS).3
- Properties
  - CAS Number
    
    681281-88-9
    
    Molecular Formula
    
    C31H27N4S·I
    
    Molecular Weight
    
    614.6
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥95%
    
    Solubility
    
    ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC[N+]1=C(/C=C/N(C2=CC=CC=C2)C)N(C3=CC=CC=C3)C4=CC=C(C5=NC(C=CC=C6)=C6S5)C=C41.[I-]
    
    * For Research Use Only
- Reference
  - 1. Wang K, Peng S, et al. "Naringin inhibits autophagy mediated by PI3K-Akt-mTOR pathway to ameliorate endothelial cell dysfunction induced by high glucose/high fat stress." Eur J Pharmacol. 2020;874:173003. PMID:32045600

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

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