Name: AIF / AIFM1 Monoclonal Antibody
Price: 180.00 USD

Overview
- Sensitivity: Endogenous
  Target name: AIF monoclonal antibody
  Area: Organelle / Mitochondria Marker
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]
Properties
- Host
  
  Mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  Human, Mouse
  
  Clone
  
  mAb
  
  Storage
  
  Store at +4°C for short term storage. Long time storage is recommended at -20°C
  Phosphate-buffered solution, pH 7.2, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative
  Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
  
  Molecular Weight
  
  67
  
  * For research use only.