AF/LE Purified Anti-Mouse CD115 Monoclonal Antibody

AF/LE Purified Anti-Mouse CD115 Monoclonal Antibody

Catalog Number:
A001088193RED
Mfr. No.:
RD21292F
Price:
$300
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      • Overview
        • Please contact us at for specific academic pricing.

          Background

          CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

      • Properties
        • Host
          rat
          Antibody Type
          monoclonal
          Isotype
          IgG2a kappa
          Reactivity
          mouse
          Formulation
          0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.
          Storage
          Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
          Concentration
          0.2 mg/mL
          Antigen
          Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD115; Csf1r; Csfmr; Fms (Gene ID:12978; UniProt:P09581)

          * For research use only.

      • Applications
        • Application
          Block; Depletion; Neutralization; Flow Cytometry; WB

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