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AEBSF.HCl

AEBSF.HCl

Catalog Number:
L002368412APE
Mfr. No.:
APE-A2573
Price:
$188
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      • Overview

        • Please contact us at for specific academic pricing.

          Background

          AEBSF is a broad spectrum, irreversible inhibitor of serine proteases [1].
          AEBSF is a covalently binding inhibitor of proteases, including trypsin, chymotrypsin, plasmin and thrombin. AEBSF was found to inhibit Aβ production in various cell lines. In K293 cells transfected with APP695 (K695sw), AEBSF showed does-dependent reduction of Aβ with IC50 value of about 1mM. In HS695 and SKN695 cells transfected with wild-type APP695, AEBSF showed inhibition effect with IC50 value of about 300 μM. AEBSF was also found to increase α-cleavege and inhibit β- cleavage. Besides that, as a protease inhibitor, AEBSF was reported to prevent monocyte-derived macrophages from lysing the leukemic cells. Incubation of macrophages with 150 μM AEBSF for 6 hours resulted in nearly maximum inhibition [1, 2].

          [1] Citron M, Diehl T S, Capell A, et al. Inhibition of amyloid β-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron, 1996, 17(1): 171-179.
          [2] Nakabo Y, Pabst M J. Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. Journal of leukocyte biology, 1996, 60(3): 328-336.

      • Properties
        • Alternative Name
          AEBSF.HCl,AEBSF Hydrochloride; 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
          CAS Number
          30827-99-7
          Molecular Formula
          C8H10FNO2S·HCl
          Molecular Weight
          239.69
          Purity
          99.49%
          Solubility
          ≥12 mg/mL in DMSO; ≥15.73 mg/mL in H2O; ≥23.8 mg/mL in EtOH with gentle warming
          Storage
          Desiccate at -20°C

          * For Research Use Only

      • Reference

        • 1. Brodie NI, Popov KI, et al."Conformational ensemble of native α-synuclein in solution as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations." PLoS Comput Biol. 2019 Mar 27;15(3):e1006859. PMID:30917118

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