Ademetionine

- Overview
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    Background
    
    Ademetionine (S-adenosylmethionine; SAMe) is a naturally occurring metabolite present in all cells and biological fluids, and acts as a methyl donor in a variety of methylation reactions involving proteins, phospholipids, catecholamines and DNA. Ademetionine exhibits antidepressant activity associated with increases in brain monoamine neurotransmitters and improvement in muscarinic and β-adrenergic receptor functions. In addition, preliminary studies imply that ademetionine exhibits therapeutic potential in the treatment of other central nervous system disorders including dementia, acquired immune deficiency syndrome-associated myelopathy, as well as brain ischemia.
    
    Reference:
    1. Bottiglieri T. Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders. Expert Opinion on Investigational Drugs, 1997, 6(4): 417-426.
- Properties
  - Categories
    
    A methyl donor
    
    Alternative Name
    
    (2S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonio)butanoate
    
    CAS Number
    
    29908-03-0
    
    Molecular Formula
    
    C15H22N6O5S
    
    Molecular Weight
    
    398.44
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; ≥108 mg/mL in H2O; ≥110.8 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C[S+](C[[email protected]](O1)([H])[[email protected]](O)([H])[[email protected]](O)([H])[[email protected]]1([H])N2C=NC(C2=NC=N3)=C3N)CC[[email protected]@](N)([H])C([O-])=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

Ademetionine

Background

Documents

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