Acid-dPEG®₉-NHS ester

Acid-dPEG®9-NHS ester, product number 10119, is a homobifunctional, amine-reactive, monodispersed PEGylation reagent that is designed to give users tight control of crosslinking reactions. Both ends of this homobifunctional crosslinker possess propionic acid groups. However, one end terminates as the N-hydroxysuccinimide (NHS) ester of propionic acid, while the opposite end terminates as the free acid. This design permits users to conjugate each end of the molecule separately. The free carboxylic acid end then either remains unreacted for charge modification or crosslinks to another amino group.

Traditional Homobifunctional Crosslinkers
Homobifunctional crosslinkers join two different molecules using the same reactive group. Traditional homobifunctional crosslinkers are hydrophobic. With hydrophobic crosslinkers, aggregation and precipitation of conjugated molecules can be a severe problem. Moreover, all homobifunctional crosslinkers tend to polymerize uncontrollably. Also, when conjugating large biomolecules such as proteins, homobifunctional crosslinkers react both intermolecularly and intramolecularly. Such mixed reactions create a wide variety of products that are difficult to characterize.

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