Name: Acetyl CoA Carboxylase 1(ACC1) Rabbit mAb
Price: 483.00 USD

Overview
- Please contact us at for specific academic pricing.
  
  Background
  
  Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzymes short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  monoclonal
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  recombinant protein
  
  Purification
  
  ProA affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
  
  Storage
  
  Store at -20°C. Avoid freeze / thaw cycles.
  
  Molecular Weight
  
  265 kDa (Calculated)
  
  Antigen
  
  Acetyl-Coenzyme A carboxylase alpha (ACC-alpha);ACC1 (Gene ID:31; UniProt:Q13085)
  
  * This product is for Research Use Only.