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Overview
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Gene Accession: NP008942
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Background
ABHD2 encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein.ABHD2 (Abhydrolase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include carboxylic ester hydrolase activity. An important paralog of this gene is ABHD3.
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