Abamectin

Abamectin

Catalog Number:
M001341903TOK
Mfr. No.:
TOK-A145
Price:
$176
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      • Overview
        • Abamectin, a natural product, is a macrocyclic lactone belonging to the Avermectin family. It is broad-spectrum insecticide (miticide and nematicide) and antiparasitic agent. It is used for agricultural and veterinary research. Abamectin is composed of avermectin B1a and avermectin B1b. These two components have similar biological properties.
          This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for questions.

          Please contact us at for specific academic pricing.

          Background

          Abamectin stimulates the release of gamma-aminobutyric acid (GABA) an inhibitory neurotransmitter. It inhbits FOF1-ATPase and the adenine nucleotide translocator (ANT), preventing mitochondrial respiration.

      • Properties
        • CAS Number
          65195-55-3 (b1a), 65195-56-4 (b1b)
          Molecular Formula
          C48H72O14 (B1a); C47H70O14 (B1b)
          Molecular Weight
          1732.14 (mixture); 873.08 (b1a); 859.06 (b1b)
          Appearance
          white to pale yellow crystal powder
          Solubility
          Soluble in DMSO. soluble in acetone, methanol, isopropanol, toluene
          Other Properties
          Source: Streptomyces avermitilis
          Purity Level: ≥90% (HPLC, B1a)
          Storage
          -20°C

          * For research use only

      • Applications
        • Application Description
          Spectrum: Effective against insects, nematodes, mites. Seed treatment for nematode control.

          Eukaryotic Cell Culture Applications: Abamectin was found to be toxic to isolated male rat hepatocytes, and 10-100 uM for 2 hrs decreased the cell viability in a time and dose-dependent manner (El-Shenawy et al, 2010).

          Insect Biology Applications: Abamectin resistance in the two-spotted spider mite is associated with cys-loop ligand-gated ion channels (CysLGIC) There are known and novel mutations in glutamate- and histamine-gated chloride channel genes. The study provides toxicological insights to explore the cysL GIC subunits as molecular targets for chemical control strategies (Dermauw et al, 2012).

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